The Diabetes Susceptibility Locus Idd5.1 on Mouse Chromosome 1 Regulates ICOS Expression and Modulates Murine Experimental Autoimmune Encephalomyelitis

Author:

Greve Bernhard,Vijayakrishnan Lalitha,Kubal Aarup,Sobel Raymond A.,Peterson Laurence B.,Wicker Linda S.,Kuchroo Vijay K.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Reference52 articles.

1. Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice

2. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/lty/Bcg genes on chromosome 1

3. NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans.

4. Further Mapping of the Idd5.1 Locus for Autoimmune Diabetes in NOD Mice

5. Wicker, L. S., G. Chamberlain, K. Hunter, D. Rainbow, S. Howlett, P. Tiffen, J. Clark, A. Gonzalez-Munoz, A. Marie Cumiskey, J. M. Howson, et al. Fine mapping, gene content, comparative gene sequencing, and expression analysis support Ctla-4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J. Immunol. In press.

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