Human cytotoxic T cell clones directed at autologous virus-transformed targets: further evidence for linkage of genetic restriction to T4 and T8 surface glycoproteins.

Author:

Meuer S C,Hodgdon J C,Cooper D A,Hussey R E,Fitzgerald K A,Schlossman S F,Reinherz E L

Abstract

Abstract Human cytotoxic T cell clones were generated against autologous EBV-transformed B lymphocytes. Whereas the majority of the clones expressed the T8 surface glycoproteins and showed a specificity for class I MHC gene products on the target cell, a minority expressed the T4 surface glycoprotein and demonstrated a class II specificity. Monoclonal antibodies to T4 and T8 inhibited cytotoxic effector function of reactive clones in a fashion analogous to their effect on alloreactive CTL clones. Each autoreactive T cell clone was cytotoxic for EBV-transformed B lymphocytes but not pokeweed mitogen-activated or resting autologous lymphocytes, suggesting a dual specificity for an MHC gene product as well as an antigen induced and/or encoded by virus. Taken together, the present findings provide further support for the notion that T4 and T8 serve as associative recognition elements on T lymphocytes for MHC gene products.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Immune Response to Virus-Infected Cells;Clinics in Immunology and Allergy;1986-02

2. Pharmacological modification of immunoregulatory activity of lymphocytes: Facts and potential1;Survey of Immunologic Research;1984-12

3. Newer lymphocyte surface antigens;Survey of Immunologic Research;1984-06

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