Minimal Information about MHC Multimers (MIAMM)

Author:

Vita Randi1ORCID,Mody Apurva1ORCID,Overton James A.2ORCID,Buus Soren3ORCID,Haley Stephen T.4ORCID,Sette Alessandro15ORCID,Mallajosyula Vamsee6ORCID,Davis Mark M.67ORCID,Long Dale L.8,Willis Richard A.8ORCID,Peters Bjoern15,Altman John D.89ORCID

Affiliation:

1. *Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA;

2. †Knocean Inc., Toronto, Ontario, Canada;

3. ‡Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark;

4. §Immudex USA, LLC, Fairfax, VA;

5. ¶Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA;

6. ‖Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, CA;

7. #Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA;

8. **Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA; and

9. ††Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA

Abstract

Abstract With the goal of improving the reproducibility and annotatability of MHC multimer reagent data, we present the establishment of a new data standard: Minimal Information about MHC Multimers (https://miamm.lji.org/). Multimers are engineered reagents composed of a ligand and a MHC, which can be represented in a standardized format using ontology terminology. We provide an online Web site to host the details of the standard, as well as a validation tool to assist with the adoption of the standard. We hope that this publication will bring increased awareness of Minimal Information about MHC Multimers and drive acceptance, ultimately improving the quality and documentation of multimer data in the scientific literature.

Funder

HHS | NIH | Office of Extramural Research, National Institutes of Health

Emory University | Yerkes National Primate Research Center, Emory University

Emory center for aids research

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

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