Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells-Reference-Cited by-同舟云学术

Cutting Edge: The Chemokine Receptor CCR8 Is Preferentially Expressed in Th2 But Not Th1 Cells

Published:1998-07-15 Issue:2 Volume:161 Page:547-551
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:

Author:

Zingoni Alessandra¹,Soto Hortensia²,Hedrick Joseph A.²,Stoppacciaro Antonella³,Storlazzi Clelia T.⁴,Sinigaglia Francesco⁵,D’Ambrosio Daniele⁵,O’Garra Anne²,Robinson Douglas²,Rocchi Mariano⁴,Santoni Angela¹²,Zlotnik Albert²,Napolitano Monica¹⁶

Affiliation:

1. *Laboratory of Pathophysiology, Regina Elena Cancer Institute, Rome, Italy;

2. †Department of Immunobiology, DNAX Research Institute, Palo Alto, CA 94304;

3. ‡Department of Experimental Medicine and Pathology, University of Rome, “La Sapienza”, Rome, Italy;

4. §Department of Genetics, University of Bari, Bari, Italy;

5. ∥Roche Institute, Milan, Italy

6. ¶Laboratory of Vascular Pathology, Istituto Dermopatico dell’Immacolata, Rome, Italy; and

Abstract

AbstractIn this paper we report on the cloning and characterization of mouse CCR8. Like its human homologue, it is predominantly expressed in the thymus. In the periphery, murine CCR8 mRNA was found most abundantly expressed in activated Th2-polarized cells and in NK1.1+CD4+ T cells. Human CCR8 is also preferentially expressed in human Th2-polarized cells and clones. This pattern of expression suggests that CCR8 is part of a Th2-specific gene expression program. The CCR8 ligands I-309 and its mouse homologue T cell activation gene 3 (TCA-3) are potent chemoattractants for Th2-polarized cells. Taken together, these observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases.

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Link

https://journals.aai.org/jimmunol/article-pdf/161/2/547/1082269/im149800547o.pdf

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