Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization-Reference-Cited by-同舟云学术

Complete Tolerogenic Adjuvant Stimulates Regulatory T Cell Response to Immunization

Published:2023-01-04 Issue:5 Volume:210 Page:609-617
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:

Author:

Zheng Guoxing¹,Geng Yajun¹²,Yan Zhaoqi¹,Shin Soo Min¹,Joshi Kanak¹^ORCID,Panicker Anjali¹^ORCID,Shankar Archana¹,Elangovan Ramya¹^ORCID,Koehler Jason¹^ORCID,Gnanasekar Varun¹^ORCID,Gilles Jessica Ann¹,Munirathinam Gnanasekar¹,Chen Aoshuang¹

Affiliation:

1. *Department of Biomedical Sciences, University of Illinois College of Medicine Rockford, Rockford, IL; and

2. †Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China

Abstract

Abstract We have determined in mice the minimum composition required for forming a vaccine adjuvant that stimulates a regulatory T (Treg) cell response to immunization, and we named the adjuvant “complete tolerogenic adjuvant.” This new kind of adjuvant may let us use the well-proven “Ag with adjuvant” form of immunization for inducing Treg cell–mediated Ag-specific immunosuppression. The minimum composition consists of dexamethasone, rapamycin, and monophosphoryl lipid A at a mass ratio of 8:20:3. By dissecting the respective role of each of these components during immunization, we have further shown why immunosuppressive and immunogenic agents are both needed for forming true adjuvants for Treg cells. This finding may guide the design of additional, and potentially more potent, complete tolerogenic adjuvants with which we may form numerous novel vaccines for treating immune diseases.

Funder

HHS | NIH | National Heart, Lung, and Blood Institute

American Diabetes Association

UofI | University of Illinois at Chicago

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Link

https://journals.aai.org/jimmunol/article-pdf/210/5/609/1644047/ji2200463.pdf

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