Cutting Edge: Identification of the Orphan Chemokine Receptor GPR-9-6 as CCR9, the Receptor for the Chemokine TECK-Reference-Cited by-同舟云学术

Cutting Edge: Identification of the Orphan Chemokine Receptor GPR-9-6 as CCR9, the Receptor for the Chemokine TECK

Published:1999-05-15 Issue:10 Volume:162 Page:5671-5675
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:

Author:

Zaballos Ángel¹,Gutiérrez Julio¹,Varona Rosa¹,Ardavín Carlos²,Márquez Gabriel¹

Affiliation:

1. *Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología, Universidad Autónoma de Madrid, Madrid, Spain; and

2. †Departamento de Biología Celular, Facultad de Biología, Universidad Complutense, Madrid, Spain

Abstract

Abstract Thymus-expressed chemokine (TECK) has been reported to chemoattract dendritic cells, thymocytes, and activated macrophages. Here, we show that TECK is a specific agonist for a human orphan receptor called GPR-9-6. We have determined the cDNA sequence of human GPR-9-6 and cloned the corresponding murine cDNA. Human and murine GPR-9-6 expression is very high in the thymus and low in lymph nodes and spleen. RT-PCR analysis of murine GPR-9-6 expression on murine FACS-sorted thymocyte subpopulations showed that this gene is expressed in both immature and mature T cells. Additions of human or murine TECK to HEK 293/human GPR-9-6 and HEK 293/murine GPR-9-6 transfectants provoked intracytoplasmic calcium mobilization. Human TECK also induced the in vitro migration of HEK 293/human GPR-9-6 cells. These results confirm that GPR-9-6 is a specific receptor for TECK. According to the established nomenclature system, we propose to rename GPR-9-6 as CC chemokine receptor 9 (CCR9).

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Link

https://journals.aai.org/jimmunol/article-pdf/162/10/5671/1100234/5671.pdf

Reference21 articles.

1. Rollins, B. J.. 1997. Chemokines. Blood 90: 909

2. Luster, A. D.. 1998. Chemokines: chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338: 436

3. Gunn, M. D., V. N. Ngo, K. M. Ansel, E. H. Ekland, J. G. Cyster, L. T. Williams. 1998. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt’s lymphoma receptor-1. Nature 391: 799

4. Legler, D. F., M. Loetscher, R. S. Roos, L. I. Clark, M. Baggiolini, B. Moser. 1998. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J. Exp. Med. 187: 655

5. Yoshida, T., T. Imai, M. Kakizaki, M. Nishimura, S. Takagi, O. Yoshie. 1998. Identification of single C motif-1/lymphotactin receptor XCR1. J. Biol. Chem. 273: 16551

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