Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death-Reference-Cited by-同舟云学术

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death

Published:2001-02-15 Issue:4 Volume:166 Page:2311-2316
ISSN:0022-1767
Container-title:The Journal of Immunology
language:en
Short-container-title:J Immunol

Author:

Wekerle Thomas,Kurtz Josef,Sayegh Mohamed H.,Ito Hiroshi,Wells Andrew D.,Bensinger Steven,Shaffer Juanita,Turka Laurence A.,Sykes Megan

Publisher

The American Association of Immunologists

Subject

Immunology,Immunology and Allergy

Reference39 articles.

1. Induction of alloantigen-specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1.

2. CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

3. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

4. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

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