Affiliation:
1. New York University School of Medicine , New York, New York 10016 and , New York, New York 10021
2. Memorial Sloan-Kettering Cancer Center , New York, New York 10016 and , New York, New York 10021
Abstract
Abstract
Under appropriate conditions of immunization combined with irradiation, SJL/J mice show a high and persistent anti-DNP IgE antibody response. Spleen cells transferred from normal untreated SJL mice suppress this response. Elimination of Ly-1+ cells, but not of Ly-2+ cells, abolished the capacity of spleen cells to suppress the IgE response.
Thus of the three T cell Ly subclasses presently identified, Ly-1, Ly-2,3, and Ly-1,2,3, the normal SJL spleen cell which suppresses the IgE response of irradiated-immunized SJL mice belongs to the Ly-1 set. It is not known whether this Ly-1 cell suppresses the IgE response directly or by helping another cell in the recipient.
The carrier-specific helper cell activity for IgE and probably IgG1 antibody response belongs to Ly-1 subclass in the SJL strain also.
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Cited by
5 articles.
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