Affiliation:
1. Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
Abstract
AbstractIL-4 is produced promptly in response to certain infections and plays a key role in the Th1/Th2 T cell dichotomy; however, the cellular source remains a matter of debate. Here we describe the induction of IL-4 in bone marrow cells of normal and RAG−/− mice by both Mycobacterium tuberculosis and its major cell wall glycolipid, lipoarabinomannan. Characterization of the cell type responsible indicated that it was distinct from the NK1+ or CD4+ T cell previously ascribed the function of rapid IL-4 secretion. Cell-sorting experiments identified CD19+/B220+ precursor cells, presumably pre-B cells that produced IL-4 constitutively and whose frequency was rapidly and markedly up-regulated by lipoarabinomannan. Thus, pathogenic mycobacteria and their glycolipids may influence hemopoiesis by rapidly inducing IL-4 secretion in the bone marrow.
Publisher
The American Association of Immunologists
Subject
Immunology,Immunology and Allergy
Reference61 articles.
1. Sonoda, Y.. 1994. Interleukin 4: a dual regulatory factor in haematopoeisis. Leukaemia Lymphoma 14: 231
2. Paul, W. E.. 1997. Interleukin 4: signalling mechanisms and control of T cell differentiation. Ciba Found. Symp. 204: 208
3. Ogawa, M.. 1993. Differentiation and proliferation of haemopoietic stem cells. Blood 81: 2844
4. Snoeck, H. W., M. Lenjou, G. Nys, F. Lardon, M. E. Peetermans, D. R. Van Boeckstaele, A. Moulijn, L. Haenen. 1996. IL-4 and IFNγ costimulate the expansion of early human myeloid colony forming cells: proposal of a model for the regulation of myelopoiesis by IL-4 and IFNγ and its integration with the regulation of the immune response. Leukemia 10: 117
5. McGinnes, K., C. J. Paige. 1991. Interleukins 1, 4, and 6 induce the colony formation of human bone marrow B lineage cells. Eur. J. Immunol. 21: 1271
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献