Affiliation:
1. Department of General Surgery, Yantai Hospital of Traditional Chinese Medicine, Yantai, Shandong, China
Abstract
IntroductionThis study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.Material and methodsFifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1–4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.ResultsGedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.ConclusionsGedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.