Affiliation:
1. Department of Public Health Medical University of Bialystok, Poland
2. Department of Immunology Medical University of Bialystok, Poland
3. Department of Analysis and Bioanalysis of Medicines Medical University of Bialystok, Poland
4. Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland
Abstract
IntroductionThe present study aimed to evaluate the diagnostic usefulness of selected novel parameters as biomarkers of hypertension: miR-145-5p, miR-1-3p, miR-423-5p, PCSK9, MyBPC3, NOX1, CYBb, and NCF2, DNase 1, anti-MPO and anti-PR3 antibodies.Material and methodsWe present the data of men with normal blood pressure, diagnosed hypertension, confirmed hypertension, hypertension and coexisting coronary artery disease.ResultsElevated levels of miR-145-5p, miR-1-3p, and miR-423-5p and high levels of PCSK9, MyBPC3, DNase 1 were observed in all groups of hypertensive men. We showed decreased levels of NOX1 and CYBb, with elevated level of NCF2.ConclusionsPCSK9 shows the greatest potential as an early biomarker of screening-detected hypertension.
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6 articles.
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