Effects of prognostic factors on overall and disease-free survival in patients with stage I–III colorectal cancer

Abstract

<b>Introduction</b>: The aim of this study was to retrospectively analyze predictive factors for overall survival (OS) and disease-free survival (DFS) rates in patients with stage I, II, or III colorectal cancer who underwent surgical treatment.<br /> <b>Material and methods</b>: Files and electronic data of 120 patients with stage I, II, or III colorectal cancer who underwent surgery between 2008 and 2012 in the Department of General Surgery of Izmir Bozyaka Research and Training Hospital were retrospectively analyzed. The effects of several prognostic factors for DFS and OS were investigated.<br /> <b>Results: </b> There were 45 (37.5%) female and 75 (62.5%) male patients; mean age was 65.51 ±11.29 years. In univariate analysis, length of DFS was found to be associated with presence of perforation, lymphovascular invasion, preoperative carcinoembryonic antigen (CEA) value and positive surgical margin. Presence of comorbidities, American Society of Anesthesiologists (ASA) score, histological grade of tumor, presence of lymphovascular invasion, preoperative CEA value, preoperative albumin value, number of metastatic lymph nodes and positive surgical margin were found to be independent prognostic factors for DFS. Cox regression analysis indicated radial surgical margin and presence of perforation had statistical significance for DFS (p value of 0.008 and 0.025, respectively). <br /> <b>Conclusions</b>: There are numerous prognostic parameters affecting postoperative survival in colorectal cancers. Prospective studies and studies on a larger scale are necessary in order to more accurately designate clinical prognostic factors that have an effect on survival time and to identify new biological and molecular markers.