The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats-Reference-Cited by-同舟云学术

The RYR3 gene is involved in Wharton’s jelly derived mesenchymal stem cell treatment of Alzheimer’s disease in rats

Published:2023-05-01 Issue:3 Volume:19 Page:820-824
ISSN:1734-1922
Container-title:Archives of Medical Science
language:
Short-container-title:Arch Med Sci

Author:

Ali Hirowati¹²³,Tofrizal Tofrizal²³⁴,Tjong Djong Hon⁵⁶,Yanis Amel³⁷,Yarni Sisca Dwi²⁶

Affiliation:

1. Department of Biochemistry, Faculty of Medicine, Andalas University, Indonesia

2. Biomedical Laboratory, Center for Integrative Biomedical Research, Andalas University, Indonesia

3. Graduate School of Biomedical Sciences, Andalas University, Indonesia

4. Department of Pathology Anatomy, Faculty of Medicine, Andalas University, Indonesia

5. Faculty of Natural Sciences and Mathematics, Andalas University, Indonesia

6. Graduate School of Biotechnology, Andalas University, Indonesia

7. Department of Psychiatry, Faculty of Medicine, Andalas University, Indonesia

Abstract

IntroductionOur study aims to observe the effect of mesenchymal stem cells (MSCs) in lowering amyloid accumulation and ryanodine receptor 3 (RYR3) gene expression, further improving cognitive dysfunction in Alzheimer’s disease (AD).Material and methodsTwenty male adult Wistar rats were randomly distributed into three groups of animals (n = 5). The AlCl3 group was given 300 mg/kg body weight (BW) of AlCl3 intraperitoneally for 5 days, further the MSC injection, and their effect after 30 days was observed.ResultsMSCs improved amyloid accumulation and Y-maze scores, and expression of the RYR3 gene decreased compared to the control group.ConclusionsMSCs improved amyloid accumulation, Y-maze scores, and RYR3 expression in the AD animal model.

Publisher

Termedia Sp. z.o.o.

Subject

General Medicine

Link

https://www.archivesofmedicalscience.com/pdf-163353-89812