The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis-Reference-Cited by-同舟云学术

The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis

Published:2023-05-01 Issue:3 Volume:19 Page:810-813
ISSN:1734-1922
Container-title:Archives of Medical Science
language:
Short-container-title:Arch Med Sci

Author:

Roszkiewicz Justyna¹^ORCID,Michałek Dominika²^ORCID,Ryk Aleksandra²^ORCID,Szmyd Bartosz³^ORCID,Smolewska Elzbieta¹^ORCID

Affiliation:

1. Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, Poland

2. Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland

3. Department of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, Poland

Abstract

IntroductionTo determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA).Material and methodsSNP genotyping was performed using genomic DNA isolated from peripheral blood samples.ResultsPatients with MTHFR rs1801133 CT/TT variant had higher values of inflammatory markers, number of joints with active arthritis, and JADAS-71 value at the baseline of MTX treatment. Children with MTRR rs1801394 AG/AA variant presented higher inflammatory marker values at JIA diagnosis.ConclusionsMTHFR rs1801133 and MTRR rs1801394 polymorphisms are associated with higher disease activity at the moment of JIA diagnosis.

Publisher

Termedia Sp. z.o.o.

Subject

General Medicine

Link

https://www.archivesofmedicalscience.com/pdf-163259-89810