Non-alcoholic Fatty Liver Disease, Metabolic syndrome, and Type 2 diabetes mellitus: Where do we stand today?

Author:

Mitrovic Bojan1,Obradovic Milan2,Gluvic Zoran1,Radunovic Maja3,Rizzo Manfredi4ORCID,Banach Maciej5ORCID,Isenovic Esma2ORCID

Affiliation:

1. University Clinical-Hospital Centre Zemun-Belgrade, Clinic of Internal medicine, School of Medicine, University of Belgrade, Serbia

2. "VINČA" Institute of Nuclear Sciences - National Institute of thе Republic of Serbia, University of Belgrade, Serbia

3. Faculty of Stomatology, Pancevo, University Business Academy, Serbia

4. Department of Internal Medicine and Medical Specialties, University of Palermo, Italy

5. Department of Hypertension, Medical University of Lodz, Poland

Abstract

Non-alcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), and type 2 diabetes (T2DM) are metabolic disorders that belong to highly prevalent disease cluster with a significant impact on public health worldwide. MetS is a complex condition characterized by metabolism perturbations that include glucose intolerance, insulin resistance, dyslipidemia, associated pro-inflammatory state and arterial hypertension. As the components of MetS commonly co-occur, the management of these disorders could not be considered separate issues. Thus NAFLD, recognized as a hepatic manifestation of MetS, is frequently associated with T2DM. This review analyzes the underlying connections between these diseases and the risks associated with their co-occurrence. The effective management of NAFLD associated with MetS and T2DM involves an early diagnosis and optimal treatment of each condition leading to improvement in glycemic and lipids regulation, liver steatosis, and arterial hypertension. The net effect of such treatment is the prevention of atherosclerotic cardiovascular diseases and liver fibrosis.

Publisher

Termedia Sp. z.o.o.

Subject

General Medicine

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