FGF-21 LEVELS AND LIVER INFLAMMATORY BIOMARKERS IN OBESE SUBJECTS AFTER WEIGHT LOSS.

Author:

Cantero Irene1,Abete Itziar2,Bullon-Vela Vanesa1,Crujeiras Ana Belen3,Casanueva F.Felipe3,Zulet M. Angeles4,Martinez J. Alfredo5

Affiliation:

1. Department of Nutrition and Physiology, University of Navarra, Pamplona. Centre for Nutrition Research, University of Navarra, Pamplona.

2. Department of Nutrition and Physiology, University of Navarra, Pamplona. Centre for Nutrition Research, University of Navarra, Pamplona. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Spain

3. Laboratory of Molecular and Cellular Endocrinology, Health Research Insitute of Santiago (IDIS), Univesity Hospital of Santiago (XXIS/SERGAS), Santiago de Compostela University (USC), Santiago de Compostela, Spain. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Spain.

4. Department of Nutrition and Physiology, University of Navarra, Pamplona. Centre for Nutrition Research, University of Navarra, Pamplona. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Spain Navarra Institute for Health Research (IdiSNA). Spain

5. Department of Nutrition and Physiology, University of Navarra, Pamplona. Centre for Nutrition Research, University of Navarra, Pamplona. CIBERobn, Physiopathology of Obesity and Nutrition. Instituto de Salud Carlos III. Spain Navarra Institute for Health Research (IdiSNA). Spain IMDEA food. Madrid. Spain

Abstract

IntroductionPrevious studies have hypothesized Fibroblast growth factor 21 (FGF-21) as a potential biomarker of the inflammation associated to liver diseases, which is also receiving high attention for its potential application concerning the management of obesity and co-morbidities. This study aimed to analyze the response of FGF-21 after a weight loss intervention and the relationships with other putative inflammatory liver biomarkers.Material and methodsSixty-six obese participants from the RESMENA study were evaluated at baseline and after following a 6-months energy restriction treatment. Anthropometrical, body composition by DXA, routine laboratory measurements, which included transaminases and gamma-glutamyl transferase (GGT) were analyzed by standardized methods. Moreover, FGF-21, M30-fragment (M30) and plasminogen activator inhibitor-1 (PAI-I) were analyzed as recognized liver inflammatory related biomarkers with specific ELISA Kits.ResultsMost measurements related with hepatic damage, inflammation and adiposity status improved at the end of the 6-months nutritional intervention. In addition, ΔFGF-21 shifts evidenced statistical relationships with changes in ΔM30, ΔGGT and ΔPAI. The reduction of M30 showed significant associations with changes in transaminases. Furthermore, PAI-I changes were related with ΔM30 and ΔGGT regardless of weight loss. A linear regression model was set up to assess the influence of ΔPAI-I and ΔM30 on the variability of ΔFGF-21 (23.8%) adjusted by weight loss.ConclusionsThese results evidenced interactions of some liver inflammatory mediators, specifically M30 and PAI-I with FGF-21. Thus, more investigation about FGF-21 is required given that this protein could be a biomarker of the obesity-inflammation-liver process.

Publisher

Termedia Sp. z.o.o.

Subject

General Medicine

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