Association between Lp(a) and T2D: a Mendelian randomization study-Reference-Cited by-同舟云学术

Association between Lp(a) and T2D: a Mendelian randomization study

Published:2024-04-20 Issue:3 Volume:20 Page:1002-1005
ISSN:1734-1922
Container-title:Archives of Medical Science
language:
Short-container-title:Arch Med Sci

Author:

Goławski Marcin¹^ORCID,Lejawa Mateusz¹^ORCID,Banach Maciej²³^ORCID,Jóźwiak Jacek⁴^ORCID,Gierlotka Marek⁵^ORCID,Osadnik Tadeusz¹^ORCID

Affiliation:

1. Department of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland

2. Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Poland

3. Ciccarone Center for the Prevention of Cardiovascular Disease, School of Medicine, Johns Hopkins University, United States

4. Department of Family Medicine and Public Health, University of Opole, Poland

5. Department of Cardiology, University Hospital, Institute of Medical Sciences, University of Opole, Poland

Abstract

IntroductionBlood lipoprotein(a) (Lp(a)) levels have been observed to be inversely correlated with type 2 diabetes (T2D). In this Mendelian randomization (MR) study, the causal impact of genetically predicted Lp(a) on T2D was assessed.MethodsA two-sample MR analysis was conducted. Data were obtained from UK Biobank and FinnGen consortia. Primary analysis was based on an inverse-variance-weighted mean (IVM) approach.ResultsNo statistically significant association between the genetically predicted levels of Lp(a) and T2D was detected (p = 0.362) in IVM analysis involving data of 563,420 patients.ConclusionsGenetically predicted Lp(a) concentration does not appear to be causally related to the risk of T2D.

Publisher

Termedia Sp. z.o.o.

Link

https://www.archivesofmedicalscience.com/pdf-187774-112112

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