Author:
De Bont S.,Bosisio F.,Garmyn M.
Abstract
Ectopic extramammary Paget on the neck
Extramammary Paget’s disease (EMPD) is a rare adenocarcinoma typically presenting as an erythematous plaque in sites with a high apocrine gland density, such as the anogenital skin and the axilla. It is rarely reported in cutaneous regions without apocrine glands, where it is classified as ectopic. To the authors’ knowledge, only 46 cases of ectopic EMPD have been reported, more frequently seen in Asians.
In this article, a remarkable case of ectopic EMPD arising on the neck of a 46-year-old Caucasian male patient is presented. Due to the non-specific clinic and the asymptomatic character, the diagnosis is often made late, which was also the case in this patient. The diagnosis is made on the basis of histological examination in combination with immunohistochemistry. Although the association with malignancy is not clear, additional imaging should be used to exclude underlying malignancy, as with EMPD. Surgical therapy is the golden standard of treatment.
Reference9 articles.
1. 1. Scarbrough CA, Vrable A, Carr DR. Definition, association with malignancy, biologic behavior, and treatment of ectopic extramammary Paget’s disease: a review of the literature. J Clin Aesthet Dermatol 2019; 12: 40-44.
2. 2. Jones RE Jr, Austin C, Ackerman AB. Extramammary Paget’s disease. A critical reexamination. Am J Dermatopathol 1979; 1: 101-132.
3. 3. Namiki T, Iikawa M, Otsuki Y, Ueno M, Yokozeki H. Ectopic extramammary Paget disease mimicking Bowen disease. J Am Acad Dermatol 2016; 75: e9-e10.
4. 4. St Claire K, Hoover A, Ashack K, Khachemoune A. Extramammary Paget disease. Dermatol Online J 2019; 25: 13030/qt7qg8g292.
5. 5. Shepherd V, Davidson EJ, Davies-Humphreys J. Extramammary Paget’s disease. BJOG 2005; 112: 273-279.
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