Study on Clinical Features and the Reproductive Hormonal Profile in Normal, Overweight and Obese Polycystic Ovarian Syndrome Women of Selected Age Group

Abstract

The objectives of the present study are to compare the clinical features among normal and PCOS women and to assess the reproductive hormonal profile of normal and PCOS women of the overweight and obese group. The normal and PCOS women were subdivided into three groups, group 1-healthy women with BMI 18.5- 24.99 (n=10), group 2 PCOS with BMI 25-29.9 (n=11) and group 3 PCOS with BMI >29.9 (n=10). The prevalence of menstrual irregularity, acne, hirsutism and obesity are the major clinical manifestations of PCOS women than the normal women of the same age group. The levels of testosterone increased and estradiol level decreased in the PCOS subjects of both overweight and obese groups. These observations in the study strongly support the presence of hyperandrogenism in PCOS women and favors all the associated clinical features. The results also clearly demonstrated the increase in body mass index reflecting a negative impact on the reproductive outcome in PCOS.