Pediyatrik kardiyak ve nonkardiyak hastalıklarda pro- BNP düzeyi ile kardiyovasküler olayların ilişkisi

Abstract

Aim We aimed to determine the relationship of Pro-BNP levels, with the diagnosis, clinical, and laboratory parameters in children. In addition, the predictive power of the Pro-BNP levels in determining the cardiovascular events was evaluated. Patients and methods: This study comprised 829 patients whose levels of Pro-BNP were measured. The data were obtained retrospectively from the hospital records. The relationship of the Pro-BNP level of the patients with the clinical, laboratory, and echocardiographic data was determined. The predictive power of the Pro-BNP and Troponin T levels in determining the development of cardiovascular events was evaluated. Results: Cardiovascular events developed in 143 patients during the follow-up period. The Pro-BNP levels were observed to be significantly higher (p< 0.001) in the group in which patients developed cardiovascular events. The Pro-BNP levels demonstrated a positive correlation with both Troponin T levels and procalcitonin levels and a strong negative correlation with the age, height, and weight of the patients. The most important predictive factors for determining the development of cardiovascular events were the presence of tachypnea, increased Pro-BNP levels, increased left ventricular end-diastolic diameter, and increased tricuspid regurgitation velocity. Conclusion: The most important determinants of a cardiovascular event, as revealed in the present study, are the presence of tachypnea, Pro-BNP levels, TR velocity, and the LVEDD z-score of patients. Moreover, the Pro-BNP levels and Troponin levels demonstrate a strong positive correlation. Randomized prospective studies are warranted to improve the efficacy of using Pro-BNP in differentiating cardiac and non-cardiac diseases in children.