Simulation of the Effect of N2O on DNA Damage by Ionizing Radiation-Reference-Cited by-同舟云学术

Simulation of the Effect of N2O on DNA Damage by Ionizing Radiation

Published:2024-07-02 Issue: Volume:4 Page:19-33
ISSN:2732-9992
Container-title:MOLECULAR SCIENCES AND APPLICATIONS
language:en
Short-container-title:

Author:

Barilla Jiří¹,Simr Pavel¹,Sýkorová Květuše¹

Affiliation:

1. Faculty of Science J. E. Purkinje University in Usti nad Labem Pasteurova 3544/1, 400 96 Usti nad Labem CZECH REPUBLIC

Abstract

Damage to the DNA molecule by ionizing radiation can be influenced by the presence of certain chemicals in the cell during irradiation. These substances can be both radioprotective and radiosensitive. In this paper, we will discuss the effect of N2O, widely used in medicine, on the chemical stage of the radiobiological mechanism. N2O in the cell during irradiation with ionizing radiation results in more significant damage to the DNA molecule because N2O reacts with hydrated electrons 𝑒𝑎𝑞 − to form aggressive OH radicals. A mathematical simulation model developed using hybrid Petri nets is used to analyze this dynamic process. Hybrid Petri nets allow us to quickly create a mathematical simulation model and explore the system under study to obtain detailed information for practical applications.

Publisher

World Scientific and Engineering Academy and Society (WSEAS)

Reference33 articles.

1. Alizadeh E., Cloutier P, Hunting D., Sanche L., Soft X-ray and Low Energy Electron Induced Damage to DNA under N2 and O2 Atmospheres. J. Phys. Chem. B 2011; 115:4523–4531. DOI: 10.1021/jp200947g

2. Alizadeh E., Sanchez L., Induction of strand breaks in DNA films by low energy electrons and soft X-ray under nitrous oxide atmosphere. Radiation Physics and Chemistry 2012; 81:33-39. DOI:10.1016/j.radphyschem.2011.09.004

3. Barilla J., Lokajíček M., The Role of Oxygen in DNA Damage by Ionizing Particles. Journal of Theoretical Biology 2000; 207:405-414. DOI:10.1006/jtbi.2000.2188

4. Barilla J., Lokajíček M., Pisaková H., et al. Analytical model of chemical phase and formation of DSB in chromosomes by ionizing radiation. Australasian Physical & Engineering Sciences in Medicine 2013; 36(1):11-17 DOI: 10.1007/s13246-012- 0179-4.

5. Barilla J., Lokajíček M., Pisaková H., et al. 2014. Simulation of the chemical stage in water radiolysis with the help of Continuous Petri nets. Radiation Physics and Chemistry 2014; 97:262-269, DOI: 10.1016/j.radphyschem.2013.12.019.