Optimized Intermittent Pharmaceutical Treatment of Cancer Using Non-Linear Optimal Control Techniques-Reference-Cited by-同舟云学术

Optimized Intermittent Pharmaceutical Treatment of Cancer Using Non-Linear Optimal Control Techniques

Published:2020-06-22 Issue: Volume:17 Page:67-75
ISSN:1109-9518
Container-title:WSEAS TRANSACTIONS ON BIOLOGY AND BIOMEDICINE
language:en
Short-container-title:

Author:

Mavromatakis Iason S.¹,Liliopoulos Sotirios G.¹,Stavrakakis George S.¹

Affiliation:

1. School of Electrical and Computer Engineering, Technical University of Crete, Chania, Crete, Greece

Abstract

Cancer remains one of the most important diseases and causes of death. In this study, a non-linear mathematical model of tumor growth with immune response, under the effects of chemotherapeutic treatment is studied. Two cost-efficient optimal control approaches are presented based on direct collocation and state dependent Riccati equation methods in order to optimize the pharmaceutical treatment-dosage to the patients. Finally, the numerical results from each method are presented, providing an overall better regimen, when compared to similar previous studies, by successfully eradicating the tumor and minimizing the side-effects of chemotherapy

Publisher

World Scientific and Engineering Academy and Society (WSEAS)

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Reference20 articles.

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