Insight into Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): Rationalized Review Special Reference to COVID-19

Abstract

The Coronavirus disease (COVID-19) is a worldwide pandemic caused by Severe acute respiratory syndrome 2 (SARS-CoV-2) which make an appearance in Wuhan China and spread globally. Coronavirus is a highly contagious virus, under the family Coronaviridae. SARS-CoV-2 causes respiratory breathing problems and can be transmitted through close contact, respiratory droplets and aerosol transmission. The binding of the structural spike proteins with the human ACE2 receptors plays a key role to initiate the event and severe complication of the disease. Clinical manifestation includes high fever, cough and dyspnoea. At present, there is no specific therapeutic strategy is available against the virus, only supportive care and management may be provided to the patients. In this review, we mainly focus and analyze the genetic morphology, pathogenesis and the therapeutic intervention. We further discuss the future perspective to confront with this viral epidemic.