Author:
Zhang Yue,Zhang Qing,Wong Clarence,Li Xuechen
Abstract
Herein, we report a highly chemoselective and
operation-simple method directly cyclizing unprotected peptides, in which <i>ortho</i>-phthalaldehyde (OPA) is found to
react with the lysine/N-terminus and cysteine within one unprotected peptide
sequence effectively to form the isoindole-bridged cyclic peptides. This
reaction is carried out in the aqueous buffer and features tolerance of diverse
functionalities, rapid and clean transformation and operational simplicity.
Publisher
American Chemical Society (ACS)
Cited by
1 articles.
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