THE ROLE OF THE GENETIC MARKER rs10824026 SYNPO2L IN THE DEVELOPMENT OF ATRIAL FIBRILLATION IN PATIENTS WITH ISCHEMIC HEART DISEASE-Reference-Cited by-同舟云学术

THE ROLE OF THE GENETIC MARKER rs10824026 SYNPO2L IN THE DEVELOPMENT OF ATRIAL FIBRILLATION IN PATIENTS WITH ISCHEMIC HEART DISEASE

Published:2022-04-20 Issue:1 Volume:3 Page:54-58
ISSN:2713-2048
Container-title:Global problems of modernity
language:ru
Short-container-title:Global'nyye problemy sovremennosti

Author:

V.N. Maksimov¹^ORCID,N.G. Lozhkina²^ORCID,E.A. Stapheeva²^ORCID,O.A. Parkhomenko³,V.V. Bezruchko³,N.Sh. Safarova³,P.P. Lozhkin

Affiliation:

1. The Institute of Internal and Preventive Medicine a branch of a federal publicly funded scientific institution «The federal research center Institute of Cytology and Genetics the Siberian Branch of the Russian Academy of Sciences» (IIPM – a branch of the ICG SB RAS), Novosibirsk, , Russian Federation

2. Novosibirsk State Medical University, Novosibirsk, Russian Federation

3. Municipal autonomous educational institution of the city of Novosibirsk "Lyceum No. 9" (MAOU "Lyceum No. 9"), Novosibirsk, Russian Federation

Abstract

Annotation: Вackground. Atrial fibrillation increases the risk of death by 5 times. The search for new genetic markers of risk will make it possible to optimize the diagnosis and treatment of this disease. Purpose of the study. To identify the most significant molecular genetic markers of atrial fibrillation in combination with coronary heart disease in residents of the Siberian region. Materials and methods. The study included female and male patients diagnosed with coronary artery disease (IHD) and atrial fibrillation (AF) (n = 100) and a comparison group of 100 people with IHD without AF, in whom the frequencies of the rs10824026 genotypes of the SYNPO2L gene were studied for polymorphic variants. Results and conclusions. In the present study, we tested the association of rs10824026 of the SYNPO2L gene with atrial fibrillation in patients with coronary artery disease. It was found that the genotype GG rs10824026 manifests itself as conditionally protective in relation to the risk of developing AF in patients with coronary artery disease.

Publisher

Technomed Holdings LLC

Subject

General Medicine

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