TOPOGRAPHIC RELATIONSHIPS OF MORPHOLOGICALLY HETEROGENEOUS ORGANS IN REACTIONS TO DEPLETED URANIUM

Abstract

Annotation: Researches of the effect of radionuclides on the human body remain relevant up to date. Their effect of penetrating the body is characterized by involvement of numerous systems of human body. The causal significance of the effects of depleted uranium exposure has not been specifically defined, however, people who live in zones of armed conflict, as well as armed forces personnel, had health problems of "unknown origin", and with remote symptomatic etiology. The risk of possible exposure is also may appear when manufacture of nose spikes for armor piercers and atomic energetics products. In view of these perspectives, depleted uranium, which used in various types of weapons, has been considered as the cause of complaints. Acute uranium intoxication is appeared in polytropic effect that is apparently depended on the resistance of the body. Getting into the internal milieu, depleted uranium exhibits radiation effect of exposure followed by alpha particles radiation. Long-term consequences after oral incorporation of depleted uranium with drinking water are matters of particular interest. The study purpose is defined by assessing of morphofunctional state of the trachea and thyroid gland, united by topographic proximity and different by morphological heterogeneity, upon one month after a single oral incorporation of an aqueous solution of depleted uranium oxides. General histological and histochemical staining methods on thin paraffin slices have been performed for studying on morphological and functional state of the trachea and thyroid gland The results of the morphological and statistical analysis of the trachea wall upon staining with hematoxylin and eosin revealed changes in the structural components that determined deformation of its functionality a month after oral incorporation of an aqueous solution of depleted uranium oxides. Morphological diagnosis was characterized by a change thickness of the epithelial layer, its multi-rowed structure, the cellular composition of the epithelium, and the loss of special organelles. Modifying effect of depleted uranium is also extended to the glandular epithelium with exposure of secretory segments hypertrophy and excretory ducts. There was revealed the diffuse lymphocyte infiltration of the tracheal membranes and formation of lymph nodules. Histochemical analysis of hormone formation in the thyroid gland has demonstrated a change in the ratio of follicles according to the degree of iodization of colloid amino acids with accurate predomination of non-iodized amino acids of irregular shape with accurate smaller diameter against target parameters, with flat or low cubic epithelium, indicating a decrease of gland functionality. The bioeffect of depleted uranium, independently from organ implementation and tissue organization, was prolonged indicating a functional inability.