STUDIES ON THE PREPARATION AND ANALYSIS OF A CHILDREN'S DOSAGE FORM WITH CHLOROPYRAMINE HYDROCHLORIDE

Abstract

Modern tasks of medicine and pharmacy are focused on the search for effective remedies for the treatment of allergic diseases, often accompanied by inflammatory processes. Very often these conditions develop in children in the form allergic dermatoses, allergic rhinitis, etc. The main nomenclature of antiallergic drugs is represented by a group of antihistamines. The classic representative of this group of drugs is chloropyramine hydrochloride, which has good anti-allergic properties. But with oral and injectable routes of administration, it causes a number of undesirable side reactions: drowsiness, vertigo dizziness, increased fatigue and headache. For local therapy of allergic reactions, soft dosage forms are the most convenient both from a pharmacological point of view and from the point of view of ease of use. This is especially true in pediatric practice, since not all children can freely swallow pills, and the injection route of administration causes painful sensations. The compositional compositions of ointments, different in their dispersological characteristics, have been studied: ointment-solution and emulsion-based ointment. As a result of biopharmaceutical studies, it was found that the emulsion base releases chloropyramine hydrochloride most intensively. The composition of the ointment is proposed: chloropyramine hydrochloride 0.2 g; PEO-4000 1.4 g; PEO-400 4.9 g; castor oil 1.0 g; emulsifier No. 1 0.3 g; twin-80 0.1 g; water 2.1 ml. To determine authenticity and quantitative analysis, a spectrophotometric method in the ultraviolet region is recommended, since the chloropyramine hydrochloride solution has maxima at wavelengths of 222, 245 and 307 nm, which allows the absorption spectrum to be used for its qualitative identification. Quantitative analysis data indicate that 0.1 g of ointment contains an average of 0.02000 g of chloropyramine hydrochloride.