COMPARATIVE POSSIBILITIES OF SCINTIGRAPHY WITH 99mTc-MIBI AND DYNAMIC COMPUTED TOMOGRAPHY IN THE DIFFERENTIAL DIAGNOSIS OF LUNG TUMORS

Abstract

Cancer is one of the most important global health problems today, and lung cancer plays a key role in this context. In Russia, more than 50,000 new cases of lung cancer are detected annually, and more than 54% of patients die from this disease in the first year after diagnosis. Computed tomography and radiography are the leading methods for diagnosing lung pathologies, including those of a tumor nature. Existing difficulties in the timely and high-quality detection of these diseases, their differential diagnosis according to various methods of radiation diagnostics, necessitate the use of special research methods. The purpose of the study was to compare the diagnostic potential of computed tomography and SPECT/CT with 99mTc-MIBI in visualization and differential diagnosis of lung malignancies by retrospectively analyzing studies of five patients with histologically verified non-small cell lung cancer. A quantitative analysis of SPECT/CT images was carried out, and the nature of accumulation and washout of the contrast agent in series of dynamic computed tomography in the areas of interest was assessed. Conclusions - SPECT with 99mTc-MIBI and dynamic computed tomography of the lungs make it possible to identify radiographic patterns typical of malignant formations, as well as to study the functional features of blood flow inside the formation. These methods, with their ability to identify characteristics of malignant blood flow in tumors, are increasingly finding application in oncology, including lung tumors, and can be used to distinguish between benign and malignant neoplasms in the lungs, early prognosis and monitoring the response to antitumor therapy.