OXIDATIVE STRESS AND THE STATE OF ANTIOXIDANT DEFENCES IN HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

Abstract: Hemorrhagic fever with renal syndrome (HFRS) is zoonotic viral disease with domination of the destabilization of cell membranes in the pathogenesis. An increase in lipid peroxidation is important in membrane damage. Circulating lipid peroxidation products affect the cell membranes of the vascular endothelium, early damage to which by the HFRS virus inevitably leads to vascular dysfunction with marked disturbance of microcirculation processes and development of organ and tissue hypoxia. The manifestation of the damaging effects of peroxide compounds is prevented by a complex system that diminishes the formation of peroxides and provides its breaking. The antioxidant system includes both enzymatic and non-enzymatic mechanisms to protect cells and subcellular structures. Therefore, at the same time study of the mechanism of the development of primary (initial) links of lipid peroxidation and dynamics of antioxidant system work in HFRS allows using more effective therapy of this severe viral infection, aimed at reducing lipid peroxidation processes and improving the quality of antioxidant system work. The aim of this study is to investigate the rate of primary lipid peroxidation processes in HFRS using the example of changes in the concentration of primary lipid peroxidation products: diene conjugates and diene ketones, and the functioning of the body's antioxidant system using the example of superoxide dismutase as the first line of defence. For a more complete evaluation of the primary lipid peroxidation processes the KDC coefficient, the ratio of diene conjugate concentrations to diene ketones, was introduced. This coefficient shows how the rate of the initial lipid peroxidation processes changes, namely the change in the concentration of diene conjugates and its further transformation to diene ketones. From the change in this coefficient, we could consider the course of the disease. When the KDC coefficient decreased, there was an increase in superoxide dismutase activity, which was accompanied by a reduction in clinical manifestations and improvement in the well-being of the patients. In the case of an increase in the KDC ratio, the activity of superoxide dismutase increases slightly, indicating an increase in the rate of the initial lipid peroxidation processes and further cell membrane damage. It seems to be associated with more severe complications that occur in the presence of some associated diseases.