HISTAMINE AS A MARKER OF CARDIORENAL SYNDROME

Abstract

Currently, the combination of chronic heart failure (CHF) and chronic kidney disease (CKD) is considered within the framework of the cardiorenal syndrome, which is associated with a high risk of adverse outcomes. The purpose of this work is to is determine the concentration of one of the most important biologically active substances – histamine and assess histamine level in patients with cardiovascular and renal pathology. The study included 498 patients: 315 patients of the main group suffering from cardiovascular diseases, some of them also having CKD; comparison group – 83 healthy patients. The levels of histamine in the blood plasma of patients were assessed by high-performance liquid chromatography combined with mass spectrometry (HPLC-MS). Based on the results of the analysis, the following data were obtained: plasma levels of histamine in patients with cardiovascular diseases were lower than in healthy patients. The lowest concentration was observed in the group of patients with CHF. Also it was found, that histamine levels are significantly associated with the presence of CKD, while a correlation analysis of histamine levels and laboratory parameters revealed a direct correlation of moderate strength between histamine levels and glomerular filtration rate (GFR) (r=0,421, p<0,000001). The results indicate the role of histamine in the pathogenesis of the cardiorenal syndrome, which requires further research in this direction.