Affiliation:
1. N.P. Ogarev National Research Mordovia State University, Saransk, Russian Federation
2. I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
3. Volgograd State Medical University, Volgograd, Russian Federation
Abstract
A clinical and laboratory study of the organ of vision, fluid media of the eye and lens tissue was carried out in order to study the pathogenetic features of the course and development of cataracts in patients with viral hepatitis B and C. An open, prospective parallel cohort clinical and pathophysiological study of 256 patients with viruses B and C and various forms of cataracts (except for congenital), who applied to the ophthalmology department of a medical organization for planned surgical treatment of diseases of the organ of vision. It was shown that the main reasons for the formation of complicated cataracts in patients, in addition to viral liver damage, were tear dysfunction syndrome, high-grade ametropia and glaucoma. The incidence of diabetes mellitus and systemic connective tissue pathology in the group of patients with chronic viral hepatitis C was statistically significantly higher than in the group of patients with viral hepatitis B and in the control group. When comparing the morphometric parameters of patients with cataracts and chronic viral hepatitis B with control parameters, no significant differences were found, while in patients with cataracts and chronic viral hepatitis C, the group average CTS indicator was statistically significantly higher than the control values. When analyzing intraoperative and postoperative complications in the study groups, it was found that the postoperative period in the majority of patients in the control group was characterized by an areactive course; in patients with CHB and C, a pronounced inflammatory reaction was observed, predominant in the group with CHC. In patients with cataracts occurring against the background of chronic viral hepatitis B and C, there was hyperenzymemia in terms of ALT depending on the form of cataract, an increased level of viral load in the peripheral blood and anterior chamber moisture and free radical activity in both the peripheral blood and the media of the eye.