Affiliation:
1. Universidade Regional do Cariri
Abstract
Objective: To identify chemical and pharmacological properties of Copaifera in the treatment of injuries and wounds. Method: Integrative literature review conducted in the LILACS, MEDLINE, PubMed, Taylor & Francis and Scopus databases in January 2022, using the search strategy: “Chemical Properties” AND “Copaifera” AND “Wounds and Injuries” and “Pharmacology” AND “Copaifera” AND “Wounds and Injuries.” Original articles, full text, identified according to level of evidence, written in Portuguese, English or Spanish, were included. Results: In the primary search 261 articles were found. After systematized selection, 12 studies were selected for qualitative analysis. Species of the genus Copaifera have pharmacological properties favorable for wound treatment: control of inflammatory pain, reduction of inflammatory reaction, tissue reepithelialization and repair, angiogenesis, wound retraction and scar remodeling. Among the chemical properties associated with the treatment of injuries, the presence of bioactive compounds stand out: diterpenes, 3-hydroxy-copalic, sesquiterpenes, kolavic-15-methyl ester. Among the tested diterpenes, kaurenoic and copalic acids showed significant hemolytic activities. Only copalic acid and hardwickiic acid inhibited nitric oxide production in lipopolysaccharide-activated macrophages. Conclusion: Plants of the genus Copaifera have chemical and pharmacological properties favorable for the treatment of injuries and wounds.
Publisher
SOBEST Associacao Brasileira de Estomaterapia
Reference30 articles.
1. Aquino VHR. Desenvolvimento de gel vaginal fitoterápico baseado em manteiga de Astrocaryum murumuru Mart contendo óleorresina de Copaifera reticulata Ducke para o tratamento de vaginose [dissertação]. Santarém: Universidade Federal do Oeste do Pará; 2019. [cited 2023 Jan 29]. Available at: https://repositorio.ufopa.edu.br/jspui/handle/123456789/484
2. Cavalcante JW, Cavalcante V, Bieski I. Conhecimento tradicional e etnofarmacológico da planta medicinal copaíba (Copaifera langsdorffii Desf.). Biodiversidade 2017;16(2):123-32.
3. Scaramuzzi IAB. Modos de orientação na floresta e as formas do entender no extrativismo comercial da castanha entre quilombolas do Alto Trombetas, Oriximiná/PA. Rev Antropol 2020;63(1):143-63. https://doi.org/10.11606/2179-0892.ra.2020.168623
4. Lima CAS, Violante IMP, Alves WKS, Carvalho FT, Silva Dias N, Anjos TR, et al. Atualizações sobre as propriedades medicinais do óleo de copaíba (Copaifera spp.): Uma revisão bibliográfica. Uniciências 2021;25(2):100-6. https://doi.org/10.17921/1415-5141.2021v25n2p100-106
5. Costa AS, Lameira OA. Estudo fitoquímico do oleorresina extraído da Copaifera reticulata Ducke (Leguminosae-Caesalpinioidade) em uma área de manejo sustentável. Res Soc Dev 2021;10(16):e154101622305. https://doi.org/10.33448/rsd-v10i16.22305