Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo-Reference-Cited by-同舟云学术

Evaluation of the prevalence of anti-erythrocyte alloimmunization in 100 polytransfused patients in Lomé, Togo

Published:2023-12-15 Issue:2 Volume:13 Page:17-27
ISSN:2230-9020
Container-title:International Journal of Blood Transfusion and Immunohematology
language:en
Short-container-title:Int J Blood Transfus Immunohematol

Author:

S Hounogbé Agboka¹,Magnang Hèzouwè²,L Nadjir Koboyo³,Etassoli Santrao⁴,Mazou Bassintou⁵,Holali Ameyapoh Adjoa⁶,Nguepou Tchopba Christelle⁶,Katawa Gnatoulma⁶,Fétéké Lochina³,Kolou Maléwé⁷

Affiliation:

1. Centre Hospitalier Universitaire Campus, Lomé, Togo

2. Ecole Supérieure des Techniques Biologiques et Alimentaires, Université de Lomé, Lomé, Togo

3. Faculté des Sciences de la Santé de l’Université de Lomé, Lomé, Togo

4. Institut National d’Assurance Maladie, Lomé, Togo

5. Centre National de Transfusion Sanguine, Lomé, Togo, Unité de Recherche en Immunologie et Immunomodulation (UR2IM)/Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA), Université de Lomé, Lomé, Togo

6. Unité de Recherche en Immunologie et Immunomodulation (UR2IM)/Laboratoire de Microbiologie et de Contrôle de Qualité des Denrées Alimentaires (LAMICODA), Université de Lomé, Lomé, Togo

7. Centre Hospitalier Universitaire Sylvanus Olympio, Lomé, Togo

Abstract

Aims: Red blood cells transfusion exposes recipients to a risk of immunization. The phenotyping of red blood cells and the search for irregular erythrocyte antibodies ensure immuno-hematological safety of the transfused patients. In Togo, these tests are not systematic in transfusion. The aim of the study was to determine the rate of immunization against erythrocyte antigens in polytransfused patients in Lomé. Methods: The search for irregular agglutinins was carried out by the indirect antiglobulin test in gel-filtration in 100 polytransfused patients selected at National Center for Research and Care of Sickle Cells disease and in the care units of Campus Teaching Hospital of Lomé in Togo, from October 1, 2021 to April 30, 2022. Results: The prevalence of alloimmunization was 27% with a total of 13 different alloantibodies identified. The most represented were anti-K (18.52%), anti-E (14.81%), anti-C (11.11%), anti-Jka (11.11%), and anti-M (11.11%). Alloantibodies were more frequent in A+ blood group patients and those who received more than 4 bags of packed red blood cells. There was no link between age, sex, and the pathologies involved on one hand, and the occurrence of anti-erythrocyte alloimmunization on the other. Conclusion: The rate of immunization against erythrocyte antigens is very high in polytransfused patients in Lomé. Systematic implementation of red blood cells phenotyping and irregular erythrocyte antibodies research before and after transfusion should ensure better immunological transfusion safety in Togo.

Publisher

Edorium Journals Pvt. Ltd.

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference21 articles.

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