Spontaneous dichorionic diamniotic twin pregnancy following a leuprolide acetate trigger and freeze all cycle for OHSS risk: A case report-Reference-Cited by-同舟云学术

Spontaneous dichorionic diamniotic twin pregnancy following a leuprolide acetate trigger and freeze all cycle for OHSS risk: A case report

Published:2023-02-28 Issue:1 Volume:9 Page:24-27
ISSN:2582-0249
Container-title:Journal of Case Reports and Images in Obstetrics and Gynecology
language:en
Short-container-title:J Case Rep Images Obstet Gynecol

Author:

White Justin¹,Gale Jenna²,Jackson Aaron¹

Affiliation:

1. Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada, Ottawa Fertility Centre, Ottawa, Ontario, Canada

2. Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada, Ottawa Fertility Centre, Ottawa, Ontario, Canada, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Abstract

Introduction: Gonadotropin-releasing hormone (GnRH) agonist triggers are increasingly used in antagonist in vitro fertilization (IVF) cycles to prevent ovarian hyperstimulation syndrome (OHSS) following a robust ovarian response. The luteolytic effects of GnRH agonists inhibit implantation or spontaneous pregnancy, warranting freezing available blastocysts for future transfer after the risk of OHSS subsides. Case Report: A 33-year-old G1P1 with secondary infertility due to polycystic ovarian syndrome underwent IVF with a GnRH antagonist cycle. A leuprolide acetate trigger for final oocyte maturation was prescribed given her risk of OHSS. A spontaneous dichorionic/diamniotic twin pregnancy ensued. Conclusion: This case reinforces the importance of advising abstinence during the stimulation phase of an IVF cycle and that, although rare, the endometrium may allow for spontaneous conception following a leuprolide acetate trigger, which may further potentiate the risk of late OHSS.

Publisher

Edorium Journals Pvt. Ltd.

Subject

General Engineering

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