We study local-global principles for two notions of semi-integral points, termed Campana points and Darmon points. In particular, we develop a semi-integral version of the Brauer–Manin obstruction interpolating between Manin’s classical version for rational points and the integral version developed by Colliot-Thélène and Xu. We determine the status of local-global principles, and obstructions to them, in two families of orbifolds naturally associated to quadric hypersurfaces. Further, we establish a quantitative result measuring the failure of the semi-integral Brauer–Manin obstruction to account for its integral counterpart for affine quadrics.