In this article, we develop a general technique for proving the uniqueness of holomorphic vertex operator algebras based on the orbifold construction and its “reverse” process. As an application, we prove that the structure of a strongly regular holomorphic vertex operator algebra of central charge
24
24
is uniquely determined by its weight
1
1
Lie algebra if the Lie algebra has the type
E
6
,
3
G
2
,
1
3
E_{6,3}G_{2,1}^3
,
A
2
,
3
6
A_{2,3}^6
, or
A
5
,
3
D
4
,
3
A
1
,
1
3
A_{5,3}D_{4,3}A_{1,1}^3
.