Although the commutative polynomial ring
F
[
x
,
y
]
F[x,y]
is a unique factorization domain (UFD) and the free associative algebra
F
⟨
x
,
y
⟩
F\langle x,y\rangle
is a similarity-UFD when
F
F
is a (commutative) field, it is shown that the polynomial ring
F
[
x
,
y
]
F[x,y]
in two commuting indeterminates is not a UFD in any reasonable sense when
F
F
is the skew field of rational quaternions.