We consider some basic properties of nonsmooth and set-valued mappings (multifunctions) connected with open and inverse mapping principles, distance estimates to the level sets (metric regularity), and a locally Lipschitzian behavior. These properties have many important applications to various problems in nonlinear analysis, optimization, control theory, etc., especially for studying sensitivity and stability questions with respect to perturbations of initial data and parameters. We establish interrelations between these properties and prove effective criteria for their fulfillment stated in terms of robust generalized derivatives for multifunctions and nonsmooth mappings. The results obtained provide complete characterizations of the properties under consideration in a general setting of closed-graph multifunctions in finite dimensions. They ensure new information even in the classical cases of smooth single-valued mappings as well as multifunctions with convex graphs.