Let
φ
(
x
,
μ
)
\varphi (x,\,\mu )
be a distribution in
x
∈
R
x \in {\mathbf {R}}
for every
μ
\mu
in a real parameter set
Ω
\Omega
. Subject to additional technical conditions, we study
m
m
th degree monic polynomials
p
m
{p_m}
that satisfy the biorthogonality conditions
\[
∫
−
∞
∞
p
m
(
x
)
d
φ
(
x
,
μ
l
)
=
0
,
l
=
1
,
2
,
…
,
m
,
m
⩾
1
\int _{ - \infty }^\infty {{p_m}(x)\,d\varphi (x,{\mu _l}) = 0,} \qquad l = 1,\,2, \ldots ,\,m,\;m \geqslant 1
\]
, for a distinct sequence
μ
1
,
μ
2
,
…
∈
Ω
{\mu _1},\,{\mu _2},\, \ldots \; \in \Omega \,
. Necessary and sufficient conditions for existence and uniqueness are established, as well as explicit determinantal and integral representations. We also consider loci of zeros, existence of Rodrigues-type formulae and reducibility to standard orthogonality. The paper is accompanied by several examples of biorthogonal systems.