Starting with Ihara’s work in 1968, there has been a growing interest in the study of zeta functions of finite graphs, by Sunada, Hashimoto, Bass, Stark and Terras, Mizuno and Sato, to name just a few authors. Then, Clair and Mokhtari-Sharghi studied zeta functions for infinite graphs acted upon by a discrete group of automorphisms. The main formula in all these treatments establishes a connection between the zeta function, originally defined as an infinite product, and the Laplacian of the graph. In this article, we consider a different class of infinite graphs. They are fractal graphs, i.e. they enjoy a self-similarity property. We define a zeta function for these graphs and, using the machinery of operator algebras, we prove a determinant formula, which relates the zeta function with the Laplacian of the graph. We also prove functional equations, and a formula which allows approximation of the zeta function by the zeta functions of finite subgraphs.