Let
G
G
be a connected reductive group, and let
X
X
be a smooth affine spherical
G
G
-variety, both defined over the complex numbers. A well-known theorem of I. Losev’s says that
X
X
is uniquely determined by its weight monoid, which is the set of irreducible representations of
G
G
that occur in the coordinate ring of
X
X
. In this paper, we use the combinatorial theory of spherical varieties and a smoothness criterion of R. Camus to characterize the weight monoids of smooth affine spherical varieties.