The purpose of this paper is to prove Ein–Lazarsfeld’s conjecture on asymptotic vanishing of syzygies of algebraic varieties. This result, together with Ein–Lazarsfeld’s asymptotic nonvanishing theorem, describes the overall picture of asymptotic behaviors of the minimal free resolutions of the graded section rings of line bundles on a projective variety as the positivity of the line bundles grows. Previously, Raicu reduced the problem to the case of products of three projective spaces, and we resolve this case here.