Genomic characteristics of classical swine fever virus strains of bovine origin according to primary and secondary sequence–structure analysis

Author:

Giangaspero Massimo,Zhang Shu-Qin

Abstract

Background: Classical swine fever virus (CSFV), species member of the family Flaviviridae, is generally considered restricted to domestic and wild suids. The circulation of CFSV has been detected in cattle herds in China and India. Natural infection appeared associated with clinical signs in some cases.Aim: The secondary structures of the internal ribosome entry site in the 5ʹ untranslated region (UTR) were used for the genomic characterization of bovine strains.Methods: Sequences have been compared to the representative CSFV strains isolated from pigs, vaccines, and contaminants from porcine cell lines and an ovine strain isolated in Spain.Results: The observed sequences from cattle showed a genetic relatedness with live-attenuated vaccine strains used in pigs. Sequence characteristics of the Chinese strain S171 are genetically distant from the previously reported CSFV genotypes, suggesting a new outgroup in the species, described for the first time, and named CSFV-d. Other Chinese strains were genetically closely related to CSFV genotype a2 (Alfort type) pig strains. Indian strains, reported from the states of Tamil Nadu and Meghalaya, were genetically closely related to CSFV genotype a1 (Brescia type) and a5 pig strains, respectively.Conclusion: These preliminary observations are new and relevant in countries, where CSFV control and eradication strategies are applied. Keywords: Cattle, Classical swine fever virus, Pestivirus, Secondary structure.

Publisher

ScopeMed

Subject

General Veterinary

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