Cytotoxic compounds from the root bark of Securidac alongipedunculata

Abstract

ABSTRACT. Chromatographic separation of the ethyl acetate extract of the root bark of Securidaca longipedunculata led to the isolation of one new xanthone derivative (1) along with nine known compounds (2-10). The structure of the isolated compounds were identified by NMR, mass spectrometric analyses, and comparison with the reported literature data. The isolates were evaluated for their cytotoxic activity with compounds 5 (IC50 = 0.38 µM) and 6 (IC50 = 52 µM) showed significant inhibitory activities against the human cervical cancer KB-3-1 cell line. Compound 5 displayed superior activity, which is even better than one of the reference drugs (griseofulvin, IC50 = 17 µM), whereas the rest showed little or none inhibitory activities.   KEY WORDS: Securidaca longipedunculata, Root bark, Xanthones, Cytotoxicity, Cervical cancer   Bull. Chem. Soc. Ethiop. 2022, 36(2), 417-422.                                                               DOI: https://dx.doi.org/10.4314/bcse.v36i2.14