Effect of low-dose lanthanum carbonate on calcium and phosphorus metabolism in Asian Patients with end-stage renal disease, maintenance hemodialysis and hyperphosphatemia
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Published:2022-08-01
Issue:2
Volume:22
Page:362-368
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ISSN:1680-6905
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Container-title:African Health Sciences
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language:
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Short-container-title:Afr H. Sci.
Author:
Cui Xiaofei,Jiang Shuning,Liu Liang,Tang Xuejie,Chen Yan
Abstract
Objective: This study aimed to examine whether a 12-week small-dose lanthanum carbonate (LaCO3; 500 mg/d) treatment could improve calcium and phosphorus metabolism and parathyroid function in Asian patients with end-stage renal disease (ESRD) under hemodialysis.
Methods: This was a prospective observational study of patients treated at our Hospital between 10/2014 and 02/2015. The patients were given 500 mg/d of LaCO3 with lunch for 12 weeks.
Results: Baseline and after 12-week treatment serum phosphorus levels were 2.49±0.51 mmol/L and 1.65±0.34 mmol/L (P<0.001). The baseline and after 12-week treatment calcium×phosphorus product were 69.40±17.34 mg2/dL2 and 44.27±9.67 mg2/dL2 (P<0.001). There was no significant difference in serum calcium and iPTH levels from baseline to after 12 weeks treatment (both P>0.05). Fourteen (25.9%) patients developed gastrointestinal adverse reactions to LaCO3and 10 patients improved after treatment.
Conclusion: Far below the 1.5-3.0g/d required by the drug instructions, LaCO3 500 mg/d for 12 weeks can still reduce serum phosphorus level and calcium × phosphorus product, without serum calcium and iPTH levels increase.
Keywords: Low dose; Lanthanum carbonate; Hyperphosphatemia; End-stage renal disease; Hemodialysis; Asian.
Publisher
African Journals Online (AJOL)
Cited by
1 articles.
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1. Editorial;African Health Sciences;2022-07-29