Clopidogrel-induced thrombotic thrombocytopenic purpura: a case report

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a rare variant of thrombotic microangiopathy. We report a case of TTP in a Nigerian chronic kidney disease (CKD) patient who was previously on clopidogrel. The features of TTP resolved soon after clopidogrel was withdrawn. Clopidogrel is a cardio-protective anti-platelet drug used in CKD patients at risk of dyspepsia. However, its potential to cause TTP should be recognized and considered in acute kidney injury (AKI) patients previously on clopidogrel. Keywords: Clopidogrel; Thrombotic Thrombocytopenic Purpura; CKD; AKI; uremic encephalopathy.