Clinicopathological pattern of oestrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 over-expression of epithelial ovarian carcinomas in Nigeria
-
Published:2023-10-11
Issue:3
Volume:23
Page:
-
ISSN:1729-0503
-
Container-title:African Health Sciences
-
language:
-
Short-container-title:Afr H. Sci.
Author:
Akanji Ajani Mustapha,Lawan Aliyu,Oke Temitope,Khramtsova Galina,Nwanji Ifeanyichukwu,Salami Ayodeji,Awolude Olutosin,Ebili Henry,E Onwukamuche Michael,Sveen Elisabeth,Yoshimatsu Toshio,I Olopade Olufunmilayo
Abstract
Background: Ovarian cancer is the leading cause of death from all gynaecological malignancies. Only few biomarkers of epithelial ovarian cancer (EOC) prognosis have been studied so far among Nigerian patients.
Objective: To determine the pattern of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) expression in patients with EOC seen in Nigeria
Materials and Methods: This was a retrospective multicentre study of 102 cases of epithelial ovarian cancers. Relevant clinical information was obtained from hospital-based records in the 3 participating centres. Tissue microarrays were constructed using representative tumour tissue and the ER, PR and HER2 immunohistochemical staining was carried out at the University of Chicago, United States of America.
Results: Serous carcinomas predominated (71% of cases). ER positivity was observed in 31.4%, PR positivity in 21.5% and HER2/neu in 16.7% of tumours. Fifty-two percent of tumours were triple negative. Serous tumours were significantly associated with ER positivity (p=0.001). Mean patient age for EOC was 52.6 ± 13.1 years. There were no statistically significant associations between hormone receptor status and histological grade, FIGO staging or survival.
Conclusion: Serous tumours were significantly associated with ER expression while non-serous tumours tended to be triple negative.
Keywords: Oestrogen receptor; Progesterone receptor; HER-2 over-expression; Epithelial ovarian cancer.
Publisher
African Journals Online (AJOL)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献