Effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants

Abstract

Purpose: To investigate the effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants. Methods: A total of 151 preterm infants admitted to the Neonatology Department, First Affiliated Hospital of Anhui Medical University,  Hefei, China, from November 2020 to June 2021 were selected. Preterm infants were randomly divided into control and study groups.  Control group received 2 % povidone-iodine and 75 % ethanol application, followed by gentle pressure with a cotton swab while the study  group received amoxicillin-clavulanate potassium applied to the umbilical cord while shaking. The management interventions were  stopped after umbilical cord separation in preterm infants, and the difference in umbilical cord separation time between the two  groups was compared. Factors associated with preterm birth conditions, hospitalization, and maternal health were identified by  univariate and multivariate logistic regression analyses. Results: The number of cases with umbilical cord separation time > 14 days was  significantly higher in the study group compared to control group (p < 0.05). The average umbilical cord separation time in the study  group was significantly lower compared to control group (p < 0.05). Univariate analysis revealed that incubator residence time  significantly affects umbilical cord separation time in preterm infants (p < 0.05). Logistic multivariate regression analysis identified  incubator residence time as the main factor influencing umbilical cord separation time in preterm infants. Conclusion: The use of  amoxicillin-clavulanate potassium shortens umbilical cord separation time, and incubator residence time is the major factor influencing  umbilical cord separation in preterm infants. Further studies should expand the study scale and increase the number of samples used.