Effect, main targets and molecular mechanisms of glycyrrhiza-derived flavonoids on malignant tumor in comprehensive cancer treatment

Abstract

Glycyrrhiza flavonoids (GF) are essential antitumor components of Glycyrrhiza uralensis, Glycyrrhiza glabra, and Glycyrrhiza inflata roots and  tubers, with antioxidant, anti-inflammatory, antibacterial, immune-enhancing amongst other properties. In recent years, significant  progress has been made in understanding the mechanisms and targets of GF in various pharmacological settings. This review summarizes the clinical value, targets and research progress of the molecular mechanisms underlying GF in the treatment of malignant  tumors. This will provide as a theoretical foundation for further studies into GF as a therapeutic option in the management of cancerous  tumors.