Synthesis, characterization, anti-microbial and cytotoxic applications of zinc(II) complexes

Abstract

ABSTRACT. In the present research, three zinc(II) complexes were synthesized using 3-(3-fluorophenyl)-2-methylacrylic acid (HL), 1,10-phenanthroline and 2,2'-pyridine as ligands. The composition, structural confirmation, coordination way of ligand and assignment of geometry to the complexes were made by different analytical tools like elemental analysis, FTIR and 1H-NMR. The ligand 3-(3-fluorophenyl)-2-methylacrylate appeared to coordinate the metal (Zn) atom via COO- moiety in all of the complexes (1-3) while 1,10-phenanthroline and 2,2'-pyridine co-ordinated to Zn(II) atom through N-donor sites in complexes 2 and 3, respectively. The complex 1 showed four while 2 and 3 showed six co-ordinated geometry. The synthesized complexes were evaluated for antimicrobial and cytotoxic activities. The obtained results showed that complexes are active against microbial agents and exhibited significant cytotoxicity.                     KEY WORDS: Co-coordination, Geometry, Zinc(II) complexes, Biological activity   Bull. Chem. Soc. Ethiop. 2021, 35(2), 287-299. DOI: https://dx.doi.org/10.4314/bcse.v35i2.6